In 1988, Tokyo was destroyed by a powerful new weapon. World War III follows, and Japan is left to rebuild from the ruins. Neo Tokyo is a city that has risen from the ashes near the crater that used to be Old Tokyo. In the streets, life can be harsh, with biker gangs running rampant and the youth difficult to keep under control. Kaneda is the leader of such a gang, and in a chance encounter, his friend Tetsuo gets injured and is taken away by the military. When Tetsuo returns, he seems to have gained some unnatural abilities, as well as the desire to prove that he’s better than everyone else. When Tetsuo gets violent and betrays Kaneda’s gang, the fight becomes personal.