Ashitaka, a prince of a hidden mountain village, suffers a strange illness after killing a monstrous wild boar. He sets off to Iron Town to find out what caused the boar to fall into a murderous rage, and possibly to find a cure for his ailment. Ashitaka discovers that in order to sustain her town, Lady Eboshi is ordering her workers to cut down the nearby forest to power their furnaces. This is making the forest spirits angry, and both sides are gearing up for war. Meanwhile, he also meets a human girl, San, who was raised among wolves in the wild. Her unique relationship with the forest spirits is Ashitaka’s only hope of reconciling man and beast.